www.mayflowerbio.com
Sales & Support: 314-485-5210

*

MOG (35-55) peptide – Myelin Oligodendrocyte Glycoprotein peptide 35-55, Mouse

Supplier:
Catalogue number:
SB023-5*1MG
Size:
5x1 mg
Product is available in:
  • USA
  • Canada
$306.25 Shipping is calculated in checkout

Myelin oligodendrocyte glycoprotein (MOG) is located on the external surface of myelin, a membranous component of the central nervous system (CNS) that forms the insulating lipid layer around neurons. The major MOG splicing variant (a1 transcript) encodes a transmembrane protein with an extracellular domain of an Ig variable (IgV) fold. MOG IgV domains from the same or different cells dimerize and contribute to the organization and maintenance of the myelin sheath in neurons. The encepalitogenic T cells recognize MOG and its immunodominant epitopes (epitopes 1-22, 35-55 and 92-106 located at the dimer interface) as foreign antigens and cause the destruction of myelin (demyelination) leading to the clinical condition known as multiple sclerosis (MS). Recognition of the antigen takes place in the context of the trimolecular complex formed by HLA, MOGpeptides and TCR.

Product Type:

Peptides & proteins

Alternative Names:

163913-87-9, AKOS030228368, KS-00000091

Related Content: