TNF-Receptor Type 1, human recombinant
TNF-alpha Receptor 1, also known as CD120a or TNF-R1, is expressed in most tissues and is activated by soluble and membrane-bound TNF-a. Activation of TNF-R1 is known to induce inflammation and apoptotic cell death, important for inhibition of tumorigenesis and viral replication, through NF-κB and MAPK pathways. The soluble form of human recombinant TNF-alpha Receptor 1 is a non-glycosylated polypeptide chain.
Peptides & proteins
TNFAR, CD120a, TNFRSF1A, TNFR55
-20°C
NAME: Tumor Necrosis Factor Receptor Type 1; ACCESSION/UNIPROT#: P19438; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5. Reconstitute in sterile water at 0.1 mg/mL.; TESTING: Neutralization of human TNF-alpha with an acceptance criteria of 100 ng/mL (ED50), 1.0 x 10^4 units/mg.; #AA: 162; SEQUENCE: MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM GQVEISSCTV DRDTVCGCKN QYRHYWSENL FQCFNCSLCL NGTVHLSCQE KQNTVCTCHA GFFLRENECV SCSNCKKSLE CTKLCLPQI EN