BMP-4, human recombinant

Bone morphogenetic protein 4 (BMP-4) is a member of the bone morphogenetic protein (BMP) family and functions in a variety of developmental processes. BMP-4 is a critical element involved in the culture and differentiation of stem cells, including differentiation in mesoderm (cardiac and skeletal muscle cells and early hematopoietic cells) and ectoderm (neural cell types and skin cell types) from pluripotent stem cells (iPSC and ESC). Human BMP-4 is fully biologically active when compared to standard. The activity is determined by the alkaline phosphatase activity induced in ATDC5 cells and it is typically less than 15 ng/ml. This corresponds to an expected specific activity of 6.7 x 104 units/mg.