Bone Morphogenic Protein 2 (BMP-2) is a member of the Bone Morphogenetic Protein (BMP) family. These proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. BMP-2 functions as a potent inducer of bone and cartilage development. Active BMP-2 consists of forming a homodimer or a heterodimer with a related BMP, such as BMP-7. BMP-2 signals through type I and type II receptor tyrosine kinases in conjuction with SMAD proteins to directly promote osteoblast differentiation. BMP-2 is also important during cardiac development and supports epicardial cell migration.
Peptides & proteins
Bone morphogenetic protein 2, bone morphogenetic protein 2A, BMP-2A, BMP2, BMP2A
1) Bao W, Gao M, Cheng Y, Lee HJ, Zhang Q, Hemingway S, Luo Z, Krol A, Yang G, An J. Biomodification of PCL Scaffolds with Matrigel, HA, and SR1 Enhances De Novo Ectopic Bone Marrow Formation Induced by rhBMP-2. (2015). Biores Open Access 4(1): 298-306.
13.0 / 26.0 kDa