www.mayflowerbio.com
Sales & Support: 314-485-5210

*

PTK787

Catalogue number:
SM80-100
Size:
100 mg
Product is available in:
  • USA
  • Canada
$314.00 Shipping is calculated in checkout

PTK787 is an inhibitor of VEGFR2/KDR, less potent against VEGFR1/Flt-1, 18-fold against VEGFR3/Flt-4. PTK787 also inhibits Flk, c-Kit and PDGFR-β. PTK787 inhibits VEGFR-dependent tumor angiogenesis and EGFR- and RET-dependent tumor cell proliferation and survival. It shows the anti-proliferation effect by inhibiting thymidine incorporation induced by VEGF in HUVECs.

Product Type:

Peptides & proteins

CAS Number:

212141-51-0

Alternative Names:

Vatalanib, CGP-79787, ZK222584, N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride

Range:

1) Zangi, L., et al. 2013. Nat Biotechnol. 31(10): 898-907. PMID: 24013197; 2) Arbab, AS. 2012. Histol Histopathol. 27(5): 549-557. PMID: 22419019; 3) Brander, D., et al. 2013. Leuk Lymphoma. 54(12): 2627-2630. PMID: 23488610

Limit of Detection:

419.73

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt