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PTK787

PTK787
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Size: 100 mg
$295.00
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Catalogue number:
SM80-100
Name:
PTK787
Supplier:
Availability:

PTK787 is an inhibitor of VEGFR2/KDR, less potent against VEGFR1/Flt-1, 18-fold against VEGFR3/Flt-4. PTK787 also inhibits Flk, c-Kit and PDGFR-β. PTK787 inhibits VEGFR-dependent tumor angiogenesis and EGFR- and RET-dependent tumor cell proliferation and survival. It shows the anti-proliferation effect by inhibiting thymidine incorporation induced by VEGF in HUVECs.

Data sheet:

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Product Type:
Peptides & proteins
CAS Number:
212141-51-0
Alternative Names:
Vatalanib, CGP-79787, ZK222584, N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride
Storage Temp:
-20°C. Keep away from direct sunlight.
Molecular Weight:
419.73
Material Safety Data Sheet:
Reference:
1) Zangi, L., et al. 2013. Nat Biotechnol. 31(10): 898-907. PMID: 24013197; 2) Arbab, AS. 2012. Histol Histopathol. 27(5): 549-557. PMID: 22419019; 3) Brander, D., et al. 2013. Leuk Lymphoma. 54(12): 2627-2630. PMID: 23488610
Shelf Life:
12 months from receipt