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IWP-2

Catalogue number:
SM39-50
Size:
50 mg
Product is available in:
  • USA
  • Canada
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IWP-2 is an inhibitor of Wnt processing and secretion. It appears that IWP inactivates Porcn function either by directly inhibiting the Porcn active site or by modulating the function of a Porcn regulator. IWP-2 promotes cardiomyocyte differentiation from human pluripotent stem cells (hPSC). This small molecule also suppresses self-renewal in mouse embryonic stem cells and supports their conversion to epiblast-like stem cells.

Product Type:

Peptides & proteins

CAS Number:

686770-61-6

Alternative Names:

Inhibitor of WNT Production-2, N-​(6-​methyl-​2-​benzothiazolyl)-​2-​[(3,​4,​6,​7-​tetrahydro-​4-​oxo-​3-​phenylthieno[3,​2-​d]pyrimidin-​2-​yl)thio]-​acetamide

Range:

1) ten Berge, D., et al. 2011. Nat Cell Biol. 13(9): 1070-1075. PMID: 21841791; 2) Chen, B., et al. 2009. Nat Chem Biol. 5(2): 100-107. PMID: 19125156

Limit of Detection:

466.6

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt