LY411575 is a potent gamma secretase inhibitor. It is able to block Notch activation and reduces A beta/42 post treatment (acute or chronic). Notch signaling is a pathway known to regulate both differentiation and proliferation of cells in diverse adult tissues. LY411575 has been shown to promote goblet cell differentiation in mice intestine. It has also been observed to promote neural differentiation of mouse embryonic stem cells (ESC).
Peptides & proteins
LY-411575, LY 411575, LSN-411575, N-2((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-l-alaninamide
1) Yu, PB., et al. 2008. Nat Med. 14(12): 1363-1369. PMID: 19029982; 2) Yu, PB., et al. 2008. Nat Chem Biol. 4(1): 33-41. PMID: 18026094; 3) Cuny, GD. 2008. Bioorg Med Chem Lett. 18(15): 4388-4392. PMID: 18621530; 4) Heisenberg, CP. and Solnica-Krezel, L. 2008. Curr Opin Genet Dev. 18(4): 311-316. PMID: 18721878
-20°C. Keep away from direct sunlight.
12 months from receipt