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LY411575

LY411575
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Size: 5 mg
$155.00
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Catalogue number:
SM25-5
Name:
LY411575
Supplier:
Availability:

LY411575 is a potent gamma secretase inhibitor. It is able to block Notch activation and reduces A beta/42 post treatment (acute or chronic). Notch signaling is a pathway known to regulate both differentiation and proliferation of cells in diverse adult tissues. LY411575 has been shown to promote goblet cell differentiation in mice intestine. It has also been observed to promote neural differentiation of mouse embryonic stem cells (ESC).

Data sheet:

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Product Type:
Peptides & proteins
CAS Number:
209984-57-6
Alternative Names:
LY-411575, LY 411575, LSN-411575, N-2((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-l-alaninamide
Storage Temp:
-20°C. Keep away from direct sunlight.
Molecular Weight:
479.48
Material Safety Data Sheet:
Reference:
1) Curry, CL., et al. 2005. Oncogene. 24(42): 6333-6344. PMID: 15940249; 2) Abranches, E., et al. 2009. PLoS One. 4(7): e6286. PMID: 19621087
Shelf Life:
12 months from receipt