Sales & Support: 314-485-5210



Catalogue number:
1 mg
Product is available in:
  • USA
  • Canada
$1119.00 Shipping is calculated in checkout

Phrixotoxin-2 (PaTx2) has been isolated originally from the venom of the Chile fire tarantula Phrixotrichus auratus. Phrixotoxin-2 is a 31 amino acid peptide that contains three disulphide bridges. Phrixotoxin-2 specifically blocks recombinant Kv4.2 and Kv4.3 currents with IC50 values of 34 nM and 71 nM, respectively. It does so by altering the gating properties of the channels. The inhibition of Kv4.2 and Kv4.3 currents is fully reversible upon washout. Kv4.1 is only slightly sensitive to Phrixotoxin-2 (maximal block of 20 by 300 nM). Kv1, Kv2 and Kv3 channel subfamilies are insensitive to this toxin.

Product Type:

Peptides & proteins

CAS Number:


Alternative Names:



Diochot S. E, et al.€ (1999) Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis. British Journal of Pharmacology.; Barfield J.P., et al. (2005) The Effects of Putative K+ Channel Blockers on Volume Regulation of Murine Spermatozoa. Biol reprod.

Limit of Detection:

3921.71 Da

Storage Temperature:


Additional Information:

AA sequence: Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp-Glu-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Leu-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Arg-Ile-Ile-Asn-Met-NH2; Disulfide bonds:Cys2-Cys16, Cys9-Cys21 and Cys15-Cys25