Autogramin-2
Supplier:
Catalogue number:
10-4439-02
Size:
25 mg
Product is available in:
Autophagy blocker GRAMD1A inhibition / Autogramin-2 is an inhibitor of autophagy (autophagy induced by amino acid starvation IC50 = 270 nM; Rapamycin IC50 = 140 nM) acting via selective targeting of the cholesterol transfer protein GRAM domain-containing protein 1A (GRAMD1A). Autogramin-2 inhibition of GRAMD1A inhibits biogenesis of the autophagosome.
Product Type:
Biochemicals & reagents
CAS Number:
2375541-45-8
Reference:
1) Laraia et al. (2019), The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis; Nat. Chem. Biol., 15 710
Storage Temperature:
-20°C
Additional Information:
PATHWAY: Cholesterol metabolism; Lipid signaling; Autophagy; Intracellular transport -- RESEARCH AREA: Cell death