Mifepristone (RU486)
Glucocorticoid antagonist / Mifepristone is a cell-permeable steroid that is a potent antagonist at the progesterone and glucocorticoid receptors.1 It is used clinically as an abortifacient. KD progesterone receptor = 2.6 nM2 and KD glucocorticoid receptor = 0.4 nM3.
Biochemicals & reagents
84371-65-3
RU486
1) Cadepond et al. (1997) RU486 (Mifepristone): Mechanisms of action and clinical uses, Annu. Rev. Med. 48 129 / 2) Terakawa et al. (1988) RU486, a progestin antagonist, binds to progesterone receptors in a human endometrial cancer cell line and reverses the growth inhibition by progestins, J. Steroid Biochem. 31 161 / 3) Jung-Testas and Baulieu (1983) Inhibition of glucocorticosteroid action in cultured L-929 mouse fibroblasts by RU486, a new anti-glucocorticosteroid of high affinity for the glucocorticoidsteroid receptor, Exp. Cell Res. 147 177
RT
TARGET: Transcription factor -- PATHWAY: Apoptosis inhibitor; Transcription; TGF-beta; Estrogen; Cytokine -- RESEARCH AREA: Cell death -- DISEASE AREA: Inflammation; Cancer