www.mayflowerbio.com
Sales & Support: 314-485-5210

*

Verrucarin A

Supplier:
Catalogue number:
10-3564-01
Size:
1 mg
Product is available in:
  • USA
  • Canada
$130.00 Shipping is calculated in checkout

Steroid receptor coactivator-3 inhibitor / A macrocyclic trichothecene mycotoxin from Myrothecium sp. It is a potent and selective inhibitor of the steroid receptor coactivator-3 and selectively down-regulates its expression.1 It is cytotoxic to multiple types of cancer cells at low nM concentrations (IC50=4.9 nM for HepG2 cells) but not toward normal liver cells.1,2 It enhances TNFα-induced3 and TRAIL-induced apoptosis4. It reduces phosphorylation of IREα and inhibits tunicamycin-induced ER stress in FaO rat liver cells.5

Product Type:

Biochemicals & reagents

CAS Number:

3148-09-2

Alternative Names:

Muconomycin-A; 379-Y; Glutinosin-I; Myrothecin-I; NSC-126728

Additional Information:

TARGET: Transcription factor -- PATHWAY: Apoptosis; Chromatin; Transcription; Protein synthesis -- RESEARCH AREA: Cellular stress; Cell death -- DISEASE AREA: Cancer