Verrucarin A
Steroid receptor coactivator-3 inhibitor / A macrocyclic trichothecene mycotoxin from Myrothecium sp. It is a potent and selective inhibitor of the steroid receptor coactivator-3 and selectively down-regulates its expression.1 It is cytotoxic to multiple types of cancer cells at low nM concentrations (IC50=4.9 nM for HepG2 cells) but not toward normal liver cells.1,2 It enhances TNFα-induced3 and TRAIL-induced apoptosis4. It reduces phosphorylation of IREα and inhibits tunicamycin-induced ER stress in FaO rat liver cells.5
Biochemicals & reagents
3148-09-2
Muconomycin-A; 379-Y; Glutinosin-I; Myrothecin-I; NSC-126728
TARGET: Transcription factor -- PATHWAY: Apoptosis; Chromatin; Transcription; Protein synthesis -- RESEARCH AREA: Cellular stress; Cell death -- DISEASE AREA: Cancer