NSC47924
PHLP phosphatase inhibitor / Laminin inhibitor / A potent inhibitor of the Leucine-rich repeat protein phosphatase (PHLPP) an enzyme which is a negative regulator of Akt and PKC (IC50=4 uM).1 Increases AKT signaling in cells and prevents apoptosis. Also inhibits the 67 kDa laminin receptor (LR) interaction with laminin (LM) and selectively blocks LR-293 cell adhesion to LM IC50=19.35 uM) impairing cell migration and invasion.2 Affects 37/67 kDa LR cell surface localization and interaction with cellular prion protein.3
Biochemicals & reagents
6638-24-0
1) Sierecki et al. (2010), Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase PHLPP by chemical and virtual screening; J. Med. Chem., 53 6899 2) Pesapane et al. (2015), Discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasion; Oncotarget, 6 18116 3) Samataro et al. (2016), The 37/67 kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67 kDa LA cell surface localization and interaction with the cellular prion protein; Sci. Rep., 6 24457
-20°C
TARGET: Phospholipase -- PATHWAY: AKT; Cell Adhesion; Apoptosis inhibitor; Cell migration -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer