DJ001
PTPsigma inhibitor / Promotes stem cell regeneration / DJ001 (2161306-12-8) is a potent and specific inhibitor of receptor type protein tyrosine phosphatase-sigma (PTPσ) IC50=1.54 uM and >10 uM for 20 other phosphatases.1 Promotes hematopoietic stem cell regeneration in vivo. In mice treated with 5-fluorouricil or irradiated, DJ001 promoted HSC regeneration accelerated hematologic recovery and improved survival. The mode of inhibition of PTPs is via non-competitive allosteric binding. Suppression of radiation-induced HSC apoptosis occurs via activation of Rho GTPase, Rac1 and induction of BCL-XL. Treatment of irradiated human HSCs with DJ001 promotes the regeneration of human HSCs capable of multilineage in vivo repopulation.1
Biochemicals & reagents
2161305-12-8
1) Zhang et al. (2019), PTP? inhibitors promote hematopoietic stem cell regeneration; Nat. Commun., 10 3667
-20°C
TARGET: Phosphatase -- PATHWAY: Bcl; Apoptosis inhibitor -- RESEARCH AREA: Stem cells; Cell death