BAY 11-7082
Supplier:
Catalogue number:
10-1296-01
Size:
10 mg
Product is available in:
IKK inhibitor / BAY 11-7082 selectively inhibits TNFα-induced phosphorylation of κ-α leading to decreased nuclear NF-κB and decreased adhesion molecule expression without affecting constitutive κ-α phosphorylation.1 The effects on adhesion molecule expression were found to be irreversible.
Product Type:
Biochemicals & reagents
CAS Number:
19542-67-7
Reference:
1) Pierce et al. (1997) Novel inhibitor of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo: J. Biol. Chem. 272, 21096
Storage Temperature:
RT
Additional Information:
TARGET: Kinase -- PATHWAY: NFkappaB; Cell adhesion; Cytokine; TNF; PI3K; ERK -- RESEARCH AREA: Oxidative stress; Neuroscience -- DISEASE AREA: Kidney disease; Inflammation