JNK-IN-8
JNK inhibitor / JNK-IN-8 is a potent and selective irreversible JNK inhibitor (IC50s=4.67, 18.7 and 0.98 nM for JNK1, 2 and 3 respectively).1 JNK blockade with JNK-IN-8 overcomes PD-L1-mediated resistance to chemotherapy in colorectal cancer.2 Improves ARDS-induced cognitive impairment by inhibition of JNK/NF-kB-mediated NLRP3 inflammasome activation.3
Biochemicals & reagents
1410880-22-6
JNK Inhibitor XVI
1 Zhang et al. (2012), Discovery of potent and selective covalent inhibitors of JNK; Chem. Biol. 19 140 2 Sun et al. (2021), Irreversible JNK blockade overcomes PD-Li-mediated resistance to chemotherapy in colorectal cancer; Oncogene 40 5105 3 Shi et al. (2023), JNK-IN-8 treatment improves ARDS-induced cognitive impairment by inhibiting JNK/NF-kB-mediated NLRP3 inflammasome; Brain Behav. 13 e2980
-20°C
TARGET: Kinase -- PATHWAY: JNK pathway; NFkappaB; Autophagy -- RESEARCH AREA: Neuroscience; Oxidative stress; Cell death -- DISEASE AREA: Cancer; NeurodegenerationInflammation