Necrostatin-1
Necroptosis inhibitor / Necrostatin-1 is an inhibitor of necroptosis (non-apoptotic cell death pathway; EC50 = 494 nM).1 It is an ATP-competitive death domain receptor-associated adaptor kinase (RIP1) inhibitor (EC50 = 182 nM).2 It displays a protective effect in a mouse model of ischemic brain injury1, inhibits myocardial cell death and reduces infarct size in various mouse heart models3 and inhibits glutamate-induced oxytosis in HT-22 cells4.
Biochemicals & reagents
4311-88-0
1) Degterev, et al. (2005), Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nature Chem. Biol. 1 112 / 2) Degterev et al (2008) Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature Chem.Biol. 4 313 / 3) Smith et.al. (2007), Necrostatin: a potentially novel cardioprotective agent?, Cardiovasc.Drugs Ther. 21 227 / 4) Xu et.al. (2007), Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells, J.Neurochem. 103 2004
RT
TARGET: Kinase -- PATHWAY: Necroptosis; Ferroptosis -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer; IschemiaHeart disease