Autophinib
Autophagy inhibitor / Inhibits autophagy induced by starvation or rapamycin by inhibiting the lipid kinase VPS34 (IC50=19 nM).1 Increased autophagy and apoptosis were rescued by autophinib in Per1-overexpressing oral squamous cell carcinoma cells.2 Autophinib has quickly become an important biochemical tool for inhibition of autophagy in a variety of cellular contexts.3-5
Biochemicals & reagents
1644443-47-9
1 Robke et al. (2017), Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34; Angew. Chem. Int. Ed. Engl., 56 8153 2 Yang et al. (2020), Loss of the clock gene Per1 promotes oral squamous cell carcinoma progression via the AKT/mTOR pathway; Cancer Sci., 111 1542 3 Yang et al. (2019), Increased expression of IncRNA CASC9 promotes tumor progression by suppressing autophagy-mediated cell apoptosis via the AKT/mTOR pathway in oral squamous cell carcinoma; Cell Death Dis., 10 41 4 Relic et al. (2021), TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells; Biochem. J., 478 3145 5 Li et al. (2022), The circadian clock gene ARNTL overexpression suppresses oral cancer progression by inducing apoptosis via activating autophagy; Med. Oncol., 39 244
-20°C
TARGET: Kinase -- PATHWAY: Autophagy; PI3K; Lipid signaling -- DISEASE AREA: Cancer