Tozasertib
Aurora kinase inhibitor / Inhibitor of Aurora kinases.1 Blocks cell cycle progressing, inhibits proliferation, and induces apoptosis in a wide range of cancer cell lines (IC50 = <10 μM for clear cell renal carcinoma).2,3
Biochemicals & reagents
639089-54-6
VX-680; MK-0457
1) Harrington et al. (2004), VX-680, a potent and selective small molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo; Nat. Med., 10 262 2) Fei et al. (2010), Activity of the Aurora kinase inhibitor VX-680 against Bcr/Abl-positive acute lymphoblastic leukemias; Mol. Cancer Ther., 9 1318 3) Dewerth et al. (2012), In vitro evaluation of the Aurora kinase inhibitor VX-680 for Hepatoblastoma; Pediatr. Surg. Int., 28 579
-20°C
TARGET: Kinase -- PATHWAY: Cell cycle; Apoptosis inducer; Proliferation -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer