Alsterpaullone
GSK3β inhibitor, CDK5/p25 inhibitor / A potent and selective inhibitor of GSK-3β and CDK5/p25. Potent inhibitor of CDK1/cyclin B (IC50 = 35 nM)1. Induces apoptosis2. Inhibits angiogenesis3.
Biochemicals & reagents
237430-03-4
1) Bain et al. (2003), The specificities of protein kinase inhibitors: an update; Biochem. J., 371 199 2) Lahusen et al. (2003), Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential.; Mol. Carcinog., 36 183 3) Zahler et al. (2010), Anti-angiogenic potential of small molecular inhibitors of cyclin dependent kinases in vitro; Angiogenesis, 13 239
RT
TARGET: Kinase -- PATHWAY: GSK3; Cell cycle; Apoptosis inducer; Wnt -- RESEARCH AREA: Angiogenesis; Cell death; Stem cells -- DISEASE AREA: Cancer