ML204
TRPC4 blocker / Selective blocker of TRPC4 channels (IC50 = 0.96 - 2.6 μM, depending on assay). Displays 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5. Has no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM. A useful tool for exploring the involvement of TRPC and TRPC-like channels in cellular signaling and physiology.2-4
Biochemicals & reagents
5465-86-1
1) Miller et al. (2011), Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels; J. Biol. Chem., 286 33436 2) Zhang et al. (2013), GIRK-like and TRPC-like conductances mediate thyrotropin-releasing hormone-induced increases in excitability in thalamic paraventricular nucleus neurons; Neuropharmacology, 72 106 3) Zhang et al. (2016), Endocannabinoid 2-AG and intracellular cannabinoid receptors modulate a low-threshold calcium spike-induced slow depolarizing afterpotential in rat thalamic paraventricular nucleus neurons; Neuroscience, 322 308 4) Zhao et al. (2015), TRP Channels Localize to Subdomains of the Apical Plasma Membrane in Human Retal Retinal Pigment Epithelium; Invest. Ophthalmol. Vis. Sci., 56 1916
-20°C
TARGET: Ion channel -- PATHWAY: Calcium signaling