Matrine
Induces RIP3-dependent necroptosis / Matrine is a natural product found in the plant Sophora flavescens. It has been found to possess myriad biological activities including a positive inotropic effect1,2, reduced glucose intolerance and hepatic steatosis in a mouse model via activation of HSP723, various anti-cancer effects4,5,6. Matrine has also recently been shown to induce RIP3-dependent necroptosis in cholangiocarcinoma cells.7
Biochemicals & reagents
519-02-8
Matridin-15-one
1) Zhou et al. (2008), Inotropic effects and mechanisms of matrine, a main alkaloid from Sophora flavescens AIT; Biol.Pharm.Bull. 31 2057 2) Zhou et al. (2014), The alkaloid matrine of the root of Sophora flavescens prevents arrhythmogenic effect of ouabain; Phytomedicine 21 931 3) Zheng et al. (2015), Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target; Br.J.Pharmacol. 172 4303 4) Li et al. (2010), Therapeutic effects of matrine on primary and metastatic breast cancer; Am.J.Chin.Med. 38 1115 5) Li et al. (2015), Matrine inhibited proliferation and increased apoptosis in human breast cancer MCF-7 cells via upregulation of Bax and downregulation of Bcl-2; Int.J.Clin.Exp.Pathol. 8 14793 6) Zhou et al. (2014), Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor; Mol.Cancer 13 Issue 59 7) Xu et al. (2017), Matrine induces RIP3-dependent necroptosis in cholangiocarcinoma cells; Cell Death Discov. 23 16096
-20°C
TARGET: HSP (Heat shock protein) -- PATHWAY: Necroptosis; Apoptosis inducer; Autophagy; Ferroptosis -- RESEARCH AREA: Cell death; Ubiquitin/Proteasome; Cellular stress -- DISEASE AREA: Cancer; DiabetesLiver disease