Mdivi
Mitochondrial division inhibitor / Selective inhibitor of Dnm1 GTPase (IC50=1-10 μM). Inhibits mitochondrial outer membrane permeabilization. Inhibits mitochondrial division and apoptosis. Cell permeable.
Biochemicals & reagents
338967-87-6
Mdivi-1
1) Cassidy-Stone et al. (2008), Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization; Dev. Cell, 14 193 2) Lackner et al. (2010), Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine; Chem. Biol., 17 578
-20°C
TARGET: GTPase -- PATHWAY: Mitochondrial function; Apoptosis inhibitor -- RESEARCH AREA: Cell death -- DISEASE AREA: Neurodegeneration; Inflammation