Nalmefene HCl
Opioid receptor antagonist / Opioid antagonist. Very similar activity profile to naloxone however displays slower onset and longer duration of action1. Antagonizes the effects of salvinorin2 (κ-agonist) as well as herkinorin3 (μ-agonist). Has been used as a therapeutic for treatment of alcohol dependence4.
Biochemicals & reagents
58895-64-0
Nalmetrene
1) Osborn et al. (2010), In vivo characterization of the opioid antagonist nalmefene in mice; Life Sci., 86 624 2) Butelman et al. (2009), Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in non-human primates: fast onset and entry in cerebrospinal fluid; J. Pharmacol. Exp. Ther., 328 588 3) Butelman et al. (2008), The effects of herkinorin, the first mu-selective ligand from salvinorin A-derived scaffold, in neuroendocrine biomarker assay in nonhuman primates; J. Pharmacol. Exp. Ther., 327 154 4) Soyka and Rosner (2008), Opioid antagonists for pharmacological treatment of alcohol dependence – a critical review; Curr. Drug Abuse Rev., 1 280
RT
TARGET: GPCR -- PATHWAY: cAMP / cGMP signaling -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Pain; Addiction