Clemastine fumarate
Histamine H1 receptor antagonist / Histamine H1 antagonist with anti-muscarinic effects at the M1 receptor. Enhances remyelination in a mouse model of demyelination.1 Displays protective role against neuroinflammation and demyelination via anti-inflammatory and anti-pyroptotic actions.2 Clemastine promoted oligodendrocyte differentiation in a rat model of spinal cord injury via muscarinic receptor mediated activation of ERK1/2 signaling.3
Biochemicals & reagents
14976-57-9
Tavist
1) Li et al. (2015), Clemastine rescues behavioral changes and enhances remyelination in the cuprizone mouse model of demyelination; Neurosci. Bull. 31 617 2) Motawi et al. (2023), Modulation of p38 MAPK and Nrf2/HO-1/NLRP3 inflammasome signaling and pyroptosis outline the anti-neuroinflammatory and remyelinating characters of Clemastine in EAE rat model; Biochem. Pharmacol. 209 115435 3) Tong et al. (2022), Clemastine Promotes Differentiation of Oligodendrocyte Progenitor Cells Through the Activation of ERK1/2 via Muscarinic Receptors After Spinal Cord Injury; Front. Pharmacol. 13 914153
-20°C
TARGET: GPCR -- PATHWAY: Histamine; Pyroptosis; ERK -- RESEARCH AREA: Neuroscience; Cell death -- DISEASE AREA: Neurodegeneration; Inflammation