Phenoxybenzamine HCl
Calmodulin antagonist / Binds to and inhibits calmodulin in a calcium-dependent and irreversible manner (IC50= ca. 1 μM)1. A classical irreversible α adrenergic antagonist2. A useful tool for irreversible inhibition of calmodulin. Cell permeable.
Biochemicals & reagents
63-92-3
1) Earl et al. (1984), Interaction of alpha adrenergic antagonists with calmodulin; Life Sci., 355 525 2) Frang et al. (2001), Phenoxybenzamine binding reveals the helical orientation of the third transmembrane domain of adrenergic receptors; J. Biol. Chem., 276 31279 3) James et al. (2009), Inhibition of nitric oxide-activated guanylylcyclase by calmodulin antagonists; Br. J. Pharmacol., 158 1454
RT
TARGET: GPCR -- PATHWAY: Calcium signaling -- DISEASE AREA: Hypertension; Pain