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Castanospermine

Supplier:
Catalogue number:
10-1132-01
Size:
10 mg
Product is available in:
  • USA
  • Canada
$50.00 Shipping is calculated in checkout

Glycosidase inhibitor / Natural product, derived from Castanospermum austral. Potent inhibitor of α- and β-glucosidases.1 Exhibits antiviral properties.2 Inhibits HIV infectivity.3 Inhibits thyroglobulin secretion.4 Castanospermine displays antitumor activity and anti-angiogenic activity.5 Prevents hyperglycemic response to oral glucose load (1 mg/kg) in rats.6

Product Type:

Biochemicals & reagents

CAS Number:

79831-76-8

Reference:

1) Saul et al. (1984), Studies on the mechanism of castanospermine inhibition of alpha- and beta-glucosidases; Arch. Biochem. Biophys, 230 668 2) Repp et al. (1985), The effects of processing inhibitors on N-linked oligosaccharides on the intracellular migration of glycoprotein E2 of mouse hepatitis virus and the maturation of coronavirus particles; J. Biol. Chem., 260 15873 3) Gruters et al. (1987), Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase; Nature, 330 74 4) Franc et al. (1990), Effects of deoxymannojirimycin and castanospermine on the polarized secretion of thyroglobulin; Endocrinology, 126 1464 5) Pili et al. (1995), The alpha-glucosidase I inhibitor castanospermine alters endothelial cell glycosylation, prevents angiogenesis, and inhibits tumor growth; Mol. Cancer Res., 55 2920 6) Rhinehart et al. (1987), Castanospermine blocks the hyperglycemic response to carbohydrates in vivo: a result of intestinal disaccharidase inhibition; Life Sci., 41 2325

Storage Temperature:

-20°C

Additional Information:

TARGET: Glycosylation -- PATHWAY: Carbohydrate metabolism; Posttranslational modification -- RESEARCH AREA: Angiogenesis -- DISEASE AREA: Infectious disease; Cancer