AZD5904
Myeloperoxidase inhibitor / A mechanism-based inactivator of myeloperoxidase (IC50 = 200 nM), reacting with hydrogen peroxide in neutrophils to inactivate the enzyme.1 This prevents production of hypochlorous acid and concomitant oxidative stress. Importantly, neutrophil bactericidal activity was slowed but not stopped. AZD5904 did not inactivate thyroid peroxidase or lactoperoxidase. AZD5904 prevented the onset and reversed established high-fat diet induced microvascular insulin resistance.2 It also alleviated the relaxation defect in hypertrophic induced pluripotent cardiomyocytes via restoration of MYBPC3 phosphorylation, suggesting potential therapeutic value in treating hypertrophic cardiomyopathy.3
Biochemicals & reagents
618913-30-7
TX4
1 Tiden et al. (2011), 2-Thioxanthines Are Mechanism-based Inactivators of Myeloperoxidase That Block Oxidative Stress during Inflammation; J. Biol. Chem. 286 37578 2 Chai et al. (2019), Inhibiting myeloperoxidase prevents onset and reverses established high-fat diet-induced microvascular insulin resistance; Am. J. Physiol. Endocrinol. Metab., 317 E1063 3 Ramachandra et al. (2022), Inhibiting cardiac myeloperoxidase alleviates the relaxation defect in hypertrophic cardiomyocytes; Cardiovasc. Res. 118 517
-20°C
TARGET: Glutathione -- PATHWAY: Mitochondrial function; Redox -- RESEARCH AREA: Oxidative stress -- DISEASE AREA: Cancer; HypertensionDiabetes; Heart disease; Inflammation