WZB117
Glucose transport inhibitor / WZB117 is an inhibitor of Glucose Transporter 1 (GLUT1). It inhibited cell proliferation in lung cancer A549 cells and breast cancer MCF7 cells with an IC50 of approximately 10 µM. Daily intraperitoneal injection of WZB117 at 10mg/kg resulted in 70% reduction in tumor volume of human A549 lung cancer grafted on nude mice
Biochemicals & reagents
1223397-11-2
1) Liu et al. (2012), A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo; Mol. Cancer Ther. 11 1672
-20°C
TARGET: Glucose transporter -- PATHWAY: Carbohydrate metabolism; Proliferation -- RESEARCH AREA: Cell death; Oxidative stress -- DISEASE AREA: Cancer; Diabetes