Endosidin 2
Exocytosis and endosomal recycling inhibitor / Endosidin-2 binds to the EXO70 subunit of the exocyst complex which results in inhibition of exocytosis and endosomal recycling in both plant and human cells and enhancement of plant vacuolar trafficking. EXO70 is a component of the octameric exocyst complex which tethers post-Golgi vesicles to the plasma membrane before SNARE- mediated membrane fusion2. Endosidin-2 was previously identified as a plant endomembrane trafficking disruptor3. It is a valuable new tool for the study of exocytosis.
Biochemicals & reagents
1839524-44-5
ES2
1) Zhang et al. (2016), Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis; Proc. Natl. Acad. Sci. USA, 113 E41 2) Novick et al. (1980), Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway; Cell, 21 205 3) Drakakaki et al. (2011),Clusters of bioactive compounds target dynamic endomembrane networks in vivol; Proc. Natl. Acad. Sci. USA, 108 17850
-20°C
TARGET: ER/Golgi -- PATHWAY: Intracellular transport -- RESEARCH AREA: Vesicles