WM-1119
KAT6A HAT inhibitor / Potent and selective inhibitor of the MYST family histone acetyltransferase KAT6A (MOZ) – IC50 = 6.3 nM.1,2 Induces cell cycle exit and cellular senescence without causing DNA damage. WM-1119 repressed the cell proliferation of sorafenib-resistant hepatocellular carcinoma cells.3
Biochemicals & reagents
2055397-28-7
1) Baell et al. (2018), Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth; Nature, 560 253 2) Priebbenow et al. (2020), Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescene-Inducing Anti-Cancer Agents; J. Med. Chem., 63 4655 3) Jin et al. (2021), KAT6A is associated with sorafenib resistance and contributes to progression of hepatocellular carcinoma by targeting YAP; Biochem. Biophys. Res. Commun., 585 185
-20°C
TARGET: Acetyltransferase -- PATHWAY: Cell cycle; Senescence; Chromatin; Posttranslational modification -- RESEARCH AREA: Epigenetics -- DISEASE AREA: Cancer