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WM-1119

Supplier:
Catalogue number:
10-4013-02
Size:
25 mg
Product is available in:
  • USA
  • Canada
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KAT6A HAT inhibitor / Potent and selective inhibitor of the MYST family histone acetyltransferase KAT6A (MOZ) – IC50 = 6.3 nM.1,2 Induces cell cycle exit and cellular senescence without causing DNA damage. WM-1119 repressed the cell proliferation of sorafenib-resistant hepatocellular carcinoma cells.3

Product Type:

Biochemicals & reagents

CAS Number:

2055397-28-7

Reference:

1) Baell et al. (2018), Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth; Nature, 560 253 2) Priebbenow et al. (2020), Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescene-Inducing Anti-Cancer Agents; J. Med. Chem., 63 4655 3) Jin et al. (2021), KAT6A is associated with sorafenib resistance and contributes to progression of hepatocellular carcinoma by targeting YAP; Biochem. Biophys. Res. Commun., 585 185

Storage Temperature:

-20°C

Additional Information:

TARGET: Acetyltransferase -- PATHWAY: Cell cycle; Senescence; Chromatin; Posttranslational modification -- RESEARCH AREA: Epigenetics -- DISEASE AREA: Cancer