Ro 415253
RARα antagonist / Selective RARα antagonist.1 Binds RARα without inducing transcription or influencing RAR/RXR heterodimerization and DNA binding.2 Inhibits proliferation and induces apoptosis in a variety of cell lines/types. Cell Permeable.
Biochemicals & reagents
144092-31-9
1) Apfel et al. (1992), A retinoic acid receptor α antagonist selectively counteracts retinoic acid effects ; Proc. Natl. Acad. Sci. USA, 89 7129 2) Toma et al. (1998), RARalpha antagonist Ro 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines; Int. J. Cancer, 78 86
-20°C
TARGET: Retinoid receptor and related; Transcription factor -- PATHWAY: Apoptosis inducer; Proliferation; Transcription -- RESEARCH AREA: Cell death; Stem cells; Neuroscience