Retinoic acid
Retinoid RAR agonist / All−trans−Retinoic acid (ATRA; a metabolite of Vitamin A) is an endogenous ligand for the retinoic acid receptor (RAR). The binding of retinoic acid to the RAR and retinoid X (RXR) heterodimer causes conformation changes in RAR that affects the binding of other proteins that regulate the growth and differentiation of a variety of both normal and malignant cells.1 ATRA promotes differentiation of embryonic stem cells (ESCs) into a variety of cell types in vitro.2-4
Biochemicals & reagents
302-79-4
ATRA; Tretinoin
1) Allenby, (1993), Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acid. Proc Natl Acad Sci USA 90 30 / 2) Dani et al (1997) Differentiation of embryonic stem cells into adipocytes in vitro. J. Cell Sci. 110 1279 / 3) Hu,, (2009) Differentiation Of Spinal Motor Neurons From Pluripotent Human Stem Cells. Nat. Protoc. 4, 1295 / 4) Sasai. (2002), Generation of dopaminergic neurons from embryonic stem cells. J. Neurol. 249, II 41
-20°C
TARGET: Retinoid receptor and related; Transcription factor -- PATHWAY: Apoptosis inducer; Transcription -- RESEARCH AREA: Stem cells; Cell death -- DISEASE AREA: Cancer