Adapalene
Retinoid RARβ/γ agonist / Stable analog of retinoic acid that acts as a selective agonist for RARß and RARγ. Also inhibits proliferation and induces apoptosis in colorectal cancer cells in culture
Biochemicals & reagents
106685-40-9
CD271
1) Michel et al. (1998), Pharmacology of Adapalene; Br. J. Dermatol., 139 Suppl. 52; 3 / 2) Ocker et al. (2003), The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells on vitro; Int. J. Cancer, 107 453 / 3) Milikan et al. (2000), Adapalene: an update on newer comparative studies between the various retinoids; Int. J. Dermatol., 39 784 / 4) Bernard et al. (1993), Adapalene, a new chemical entity with retinoid activity; Skin Pharmacol., 6 61
RT
TARGET: Retinoid receptor and related; Transcription factor -- PATHWAY: Apoptosis inducer; Proliferation; Transcription -- RESEARCH AREA: Cell death -- DISEASE AREA: Cancer