ERGi-USU
Supplier:
Catalogue number:
10-4290-01
Size:
10 mg
Product is available in:
ERG inhibitor / ERGi-USU selectively inhibits the growth of ERG-positive VCaP prostate cancer cells, COLO320 colon cancer cells, KG-1 and MOLT-4 leukemia cells with minimal effect on ERG-negative cells or normal prostate or endothelial cells (IC50 = 169 nM for cell growth and 315 nM for ERG protein in VCaP cells). It selectively inhibits the kinase RIOK2 (Kd = 200 nM) causing disruption of ribosomal biogenesis and ribosomal stress.
Product Type:
Biochemicals & reagents
CAS Number:
1147-56-4
Alternative Names:
NSC139021
Reference:
1) Mohamed et al. (2018), Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth; Cancer Res. 78 3659
Storage Temperature:
-20°C
Additional Information:
TARGET: Kinase; Transcription factor -- PATHWAY: Protein synthesis; Transcription -- DISEASE AREA: Cancer