Cafestol
Neuroprotective / Cafestol is a bioactive diterpene found in coffee.1 It displays a number of interesting protective effects including stimulation of glutathione S-transferase activity1, and protection against aflatoxin-induced genotoxicity2. It produces neuroprotective effects in Drosophila models of Parkinson’s disease3 and in other models4. In humans cafestol raises serum cholesterol and acts as an agonist at farnesoid and pregnane X receptors.5
Biochemicals & reagents
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1 Lam et al. (1982), Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse; Cancer Res. 42 1193 2 Cavin et al. (1998), The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism; Carcinogenesis 19 1369 3 Trinh et al. (2010), Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson’s disease through an NRF2-dependent mechanism; J. Neurosci. 30 5525 4 Socala et al. (2020), Neuroprotective Effects of Coffee Bioactive Compounds: A Review; Int. J. Mol. Sci. 22 107 5 Ricketts et al. (2007), The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors; Mol. Endocrinol. 21 1603
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TARGET: Antioxidant; Transcription factor -- PATHWAY: Cytokine; NFkappaB; MAPK; ERK; Cholesterol metabolism -- RESEARCH AREA: Oxidative stress -- DISEASE AREA: Neurodegeneration; CancerInflammation