Anacardic acid
HAT inhibitor / Anacardic acid is a natural product found in cashew nut oil. It is an inhibitor of the histone acetyltransferases p300 and PCAF (IC50’s = 8.5 and 5.0 µM respectively).1 Anacardic acid sensitizes cancer cells to ionizing radiation2 and suppresses proteins involved in invasion and angiogenesis (Src/FAK/Rho GTPases3 and MMP’s 2 (IC50 = 11.11 µM)4 and 9). It inhibits both inducible and constitutive NF-κB activation.5
Biochemicals & reagents
16611-84-0
6-Pentadecylsalicylic acid; 6-PDSA
1) Balasubramanyam et al. (2003), Small molecule modulators of histone acetyltransferase p300; J.Biol.Chem. 278 19134 2) Sun et al. (2006), Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation; FEBS Lett. 580 4353 3) Wu et al. (2011), Anacardic acid (6-Pentadecylsalicylic acid) Inhibits Tumor Angiogenesis by Targeting Src/FAK/Rho GTPases Signaling Pathway; J.Pharmacol.Exp.Ther. 339 403 4) Omanakuttan et al. (2012), Anacardic acid Inhibits the Catalytic Activity of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9; Mol.Pharmacol. 82 614 5) Sung et al. (2008), Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kB- regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kBα kinase, leading to potentiation of apoptosis; Blood 111 4880
-20°C
TARGET: Acetyltransferase; Protease -- PATHWAY: Chromatin; NFkappaB; Posttranslational modification; Cell adhesion; MAPK; Cytokine -- RESEARCH AREA: Epigenetics; Angiogenesis; Stem cells; Immunology -- DISEASE AREA: Cancer; Inflammation