LY171883
CysLT1 antagonist / LY-171883 is a selective and orally active leukotriene D4 (LTD4) antagonist (Ki = 0.63 µM).1 It is also an activator of peroxisome proliferator-activated receptors (PPAR’s).2,3
Biochemicals & reagents
88107-10-2
1) Fleisch et al. (1985), LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5-yl)butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist; J.Pharmacol.Exp.Ther., 233 148. / 2) Foxworthy and Eacho (1991) Effect of the peroxisome proliferator LY171883 on triglyceride accumulation in rats fed a fat-free diet. Biochem.Pharmacol. 42 1487 / 3) Kliewer et al. (1994) Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc.Natl.Acad.Sci.USA 91 7355
-20°C
TARGET: Leukotriene receptor; PPAR -- PATHWAY: Lipid signaling; PPAR; Transcription -- DISEASE AREA: Hypertension; InflammationCancer