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GaTx2

GaTx2
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Size: 0.1 mg
$292.00
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Catalogue number:
10GTX002-00100
Name:
GaTx2
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GaTx2 (gating modifier of anion channels 2) was isolated from the venom of Leiurus quinquestriatus hebraeus. GaTx2 is the most potent peptide inhibitor of ClC-2 chloride channel ever described. Kd value is close to 20 pM. GaTx2 slows ClC-2 activation but without altering channel conductance. The effect is voltage-dependent. It has no effect on ClC-0, ClC-1, ClC-3, ClC-4, CFTR, GABAC, Xenopus ClCa, Shaker B or Kv1.2 channels. Structurally, GaTx2 is composed of two β-strands and one α-helix. This peptide is also called Leiuropeptide II. Bears 89, 93 and 96% identity with OdK1, neurotoxin PO1 and leiuropeptide III, respectively.

Product Type:
Peptides & proteins
Storage Temp:
RT
Molecular Weight:
3191.29 Da
Reference:
Thompson CH, et al. (2009) J Biol Chem; Eric E, et al. (2013) Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia. Am J Physiol Lung Cell Mol Physiol