NY-ESO-1 (157-165)

NY-ESO-1 protein: NY-ESO-1 (157-165) is an epitope analogue of the New York esophageal squamous cell carcinoma-1, also named cancer testis. NY-ESO-1 is expressed in 82% of neuroblastomas and 46% of melanomas but also in many others solid tumors and hematological malignancies. That’s why, NY-ESO-1 peptides are attractive targets for specific immunotherapies and for the stimulation of human NY-ESO-1 specific CD8+ T cells. Applications of NY-ESO-1 (157-165): NY-ESO-1 (157-165) is used to stimulate specific cytotoxic T cells in PBMCs and to analyze by ELISPOT peptide epitope specificity and cytokine production like IFN-γ. NY-ESO-1 (157-165) contains epitope capable of binding HLA-A2 molecules. NY-ESO-1 (157-165) has been used with adjuvant in protein nanoparticles in order to study cell-mediated immune responses. NY-ESO-1 (157-165) is also used in clinical trial to study the immunological effects of a vaccine composed of NY-ESO-1 (157-165).