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Phosphorylation is a reversible post-translational modification. Abnormal protein phosphorylation is a cause or consequence of disease, including cancers, diabetes and inflammatory disease, while defects in genes that encode protein kinases and phosphatases underlie a number of inherited disorders. Approximately 500 protein kinases are encoded in the human genome and they account for nearly 25% of the molecular targets currently being pursued by drug discovery companies.

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