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Kinase Modulator Array Library

Library Code: T-VDAKinase
Kinases are prime drug targets for a wide range of disease areas including neurology, ophthalmology and oncology. Venoms are proving a rich source of new molecules to meet the need for novel approaches to targeting these useful mechanisms. Research has been published on novel peptides and proteins with kinase activity1 found in snake venoms, and our own research has identified several key invertebrate venoms. The Kinase Targeted Venom Discovery Array™ libraries contain pure venom fractions from 12, 24, 48 or 96 species optimized for identification of novel tools. Each array contains literature-cited, characterized venoms with kinase binding activity from the literature as positive controls. Other venom fractions making up the library have been specially selected by our drug discovery scientists to maximize novel hit potential.
T-VDAKinase control venoms include:
  • Naja atra (Chinese cobra), which contains unique three finger neurotoxins that bind Protein Kinase C1
  • Deinagkistrodon acutus (hundred pace pit viper) venom, which contains snaclec agglucetin, a lectin that signals through phosphatidylinositol 3-kinase (PI3K)2
  1. Chiou SH, Raynor RL, Zheng B, Chambers TC, Kuo JF. (1993). Cobra venom cardiotoxin (cytotoxin) isoforms and neurotoxin: comparative potency of protein kinase C inhibition and cancer cell cytotoxicity and modes of enzyme inhibition. Biochemistry. 2;32(8):2062-7.
  2. Wang WJ. (2008). Agglucetin, a tetrameric C-type lectin-like venom protein, regulates endothelial cell survival and promotes angiogenesis by activating integrin alphavbeta3 signaling. Biochem. Biophys. Res. Commun. 2;369(2):753-60.
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