Ion Channel Modulators
Inhibitors and modulators are available for a wide range of ion channel targets.
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Ion Channel Categories
Ionotropic Glutamate Receptors |
5-HT3 Receptors
Clomipramine Hydrochloride (FIASMA, mAChR, 5-HT2/3/6/7, α1/2-adrenergic antagonist, SERT and NET inhibitor, hERG K+ and L-type Ca2+ channel blocker) Dolasetron (5-HT3 antagonist) Dolasetron Mesylate Hydrate (5-HT3 antagonist) Fluvoxamine Maleate (FIASMA, 5-HT3 and σ1 agonist, SERT inhibitor) 8-Gingerol (5-HT3 antagonist) 10-Gingerol (5-HT3 antagonist) Granisetron Hydrochloride (5-HT3 antagonist) Memantine Hydrochloride (D2 agonist, NMDA, 5-HT3, α7 nAChR antagonist) 5-Methoxyindole (potential PPARγ and 5-HT3 agonist) Ondansetron Hydrochloride Dihydrate (5-HT3 antagonist) Ramosetron (5-HT3 antagonist) Shogaol (PPARγ agonist, 5-HT3 antagonist) Tropisetron Hydrochloride (α7 nAChR partial agonist, 5-HT3 antagonist) |
Acid-sensing Channels
Amiloride Hydrochloride Dihydrate (ENaC and acid-sensing ion channel blocker, Na+/H+ antiporter inhibitor) Oxytocin (OXTR agonist, acid-sensing ion channel blocker) RF-NH2 (potential GPR147 agonist, potential acid-sensing ion channel activator) Sinomenine Hydrochloride (acid-sensing ion channel and L-type Ca2+ channel blocker) |
Calcium Channels
Allicin (inwardly rectifying K+ channel activator, L-type Ca2+ channel blocker) Allicin, aqueous (Kir K+ channel activator, L-type Ca2+ channel blocker) Amiodarone Hydrochloride (Voltage-gated Na+, Ca2+, K+ channel blocker, α/β-adrenergic antagonist, FIASMA) Amitriptyline Hydrochloride (FIASMA, σ1, RyR2, TrkA/B agonist, 5-HT2/6/7, M1-5 mAChR, histamine H1/4, α1-adr. antagonist, SERT, NET inhibitor, Kv1.1/7.2/7.3 K+, L-type Ca2+ channel blocker) Amlodipine (FIASMA; L-type Ca2+ channel blocker) Amlodipine Besylate (FIASMA; L-type Ca2+ channel blocker) Catharanthine base (voltage-gated Ca2+ channel blocker) Catharanthine Sulfate (voltage-gated Ca2+ channel blocker) Catharanthine Tartrate (voltage-gated Ca2+ channel blocker) Cilnidipine (L-type and N-type Ca2+ channel blocker) Cinnarizine (FIASMA, L-type Ca2+ channel blocker, D2 antagonist) Clomipramine Hydrochloride (FIASMA, mAChR, 5-HT2/3/6/7, α1/2-adrenergic antagonist, SERT and NET inhibitor, hERG K+ and L-type Ca2+ channel blocker) Cyproconazole (14-α demethylase inhibitor, voltage-gated Ca2+ channel blocker, potential aromatase inhibitor) Dantrolene Sodium Heptahydrate (RyR antagonist, L-type Ca2+ channel blocker) Deoxyandrographolide (cNOS and adenylyl cyclase activator, PAF inhibitor, potential voltage-gated Ca2+ channel blocker) Dihydromethysticin (Voltage-gated Na+ and L-type Ca2+ channel blocker) Diltiazem Hydrochloride (L-type Ca2+ channel blocker, potential CNG channel blocker) Dimebon Dihydrochloride (AMPK activator, L-type Ca2+ channel and NMDA, histamine H1/2, α-adrenergic, 5-HT2C/5A/6 receptor antagonist) Felodipine (L-type Ca2+ channel blocker) Gabapentin (GABA potentiator, adenosine A1 agonist, voltage-gated α2δ Ca2+ channel blocker, NMDA modulator) Glucagon (19-29), human (potential Ca2+ channel blocker) Hesperetin (L-type Ca2+ channel blocker) Hypericin (dopamine β-hydroxylase and proteasome inhibitor, N-type and P/Q-type Ca2+ channel blocker) Kawain (Voltage-gated Na+ and L-type Ca2+ channel blocker) Lamotrigine (R-type Ca2+ and voltage-gated Na+ channel blocker) Lomerizine Dihydrochloride (L-type and T-type Ca2+ and TRP antagonist) Manidipine Dihydrochloride (L-type and N-type Ca2+ channel blocker) Maprotiline Hydrochloride (FIASMA, histamine H1, 5-HT2, mAChR, α1-adrenergic antagonist, L-type Ca2+ channel blocker, NET inhibitor) Nefiracetam (NMDA and mGluR5 agonist, N-type and L-type Ca2+ channel activator, α4β2 nAChR potentiator) Nicardipine (L-type Ca2+ channel blocker) Nifedipine (L-type Ca2+ channel blocker) Niflumic Acid (NMDA inverse agonist, T-type Ca2+ and Cl- channel blocker, GABA-A antagonist, COX-1/2 inhibitor) Nimodipine (L-type Ca2+ channel blocker) Paeoniflorin (L-type Ca2+ channel blocker) Paeonol (MAO-A/B inhibitor, voltage-gated and receptor-gated Ca2+ channel blocker) Panaxadiol (voltage-gated Ca2+ channel blocker) Panaxatriol (voltage-gated Ca2+ channel blocker) Penicillic Acid (BK K+, voltage-gated cardiac Na+, K+, Ca2+ channel inhibitor) Praziquantel (potential adenosine antagonist, potential voltage-gated Ca2+ channel blocker) Protopine (voltage- and receptor-gated Ca2+ channel blocker) Rhyncholphylline (hERG K+ and L-type Ca2+ channel channel blocker, NMDA antagonist) Roscovitine (CDK inhibitor, L-type Ca2+ channel blocker) Simvastatin (HMG-CoA reductase inhibitor, potential ATP-sensitive K+ channel activator, L-type Ca2+ channel blocker) Sinomenine Hydrochloride (acid-sensing ion channel and L-type Ca2+ channel blocker) Snake venom - Crotalus durissus terrificus (binds N-type and P/Q-type Ca2+ channels, L-type Ca2+ channel potentiator, NMJ blocker) Somatostatin-14 (somatostatin agonist, GABA modulator, P/Q-type, N-type, and L-type voltage-gated Ca2+ channel modulator) Somatostatin-25 (somatostatin agonist, GABA modulator, P/Q-type, N-type, and L-type voltage-gated Ca2+ channel modulator) Somatostatin-28 (somatostatin agonist, GABA modulator, P/Q-type, N-type, and L-type voltage-gated Ca2+ channel modulator) Somatostatin-28 (1-12) (somatostatin agonist, GABA modulator, P/Q-type, N-type, and L-type voltage-gated Ca2+ channel modulator) Somatostatin-28 (1-14) (somatostatin agonist, GABA modulator, P/Q-type, N-type, and L-type voltage-gated Ca2+ channel modulator) [Tyr1]-Somatostatin (somatostatin agonist, GABA modulator, P/Q-type, N-type, and L-type voltage-gated Ca2+ channel modulator) [Tyr11]-Somatostatin (somatostatin agonist, GABA modulator, P/Q-type, N-type, and L-type voltage-gated Ca2+ channel modulator) Tebuconazole (14-α demethylase inhibitor, voltage-gated Ca2+ channel blocker, potential aromatase inhibitor) S,S-(+)-Tetrandrine (voltage-gated Ca2+ channel blocker) D,L-Tetrahydropalmatine (D1/2 antagonist, potential L-type Ca2+ and K+ channel blocker) Trimebutine Base (BK K+ channel and L-type Ca2+ channel blocker) Trimebutine Maleate (L-type Ca2+ channel blocker, BK K+ channel modulator, potential opioid agonist) Valproic Acid Sodium (T-type Ca2+ and voltage-gated Na+ channel blocker, GABA transaminase and HDAC inhibitor) Verapamil Hydrochloride (L-type Ca2+ channel blocker) Zonisamide (carbonic anhydrase inhibitor, voltage-gated Na+ and T-type Ca2+ channel blocker) |
Chloride Channels
Aloe Emodin (CTFR Cl- channel activator) Cromolyn Sodium (potential TRP antagonist, potential Cl- channel blocker) Emodin (CTFR Cl- channel activator) Furosemide (NKCC symporter inhibitor, CFTR Cl- channel blocker, GABA-A antagonist) Ivermectin (glu-gated Cl- channel activator, GlyR and GABA-A agonist) Niflumic Acid (NMDA inverse agonist, T-type Ca2+ and Cl- channel blocker, GABA-A antagonist, COX-1/2 inhibitor) Triacetyl Aloe-emodin (Impurity A) (CFTR Cl- channel activator) |
CNG Channels
Amitriptyline Hydrochloride (FIASMA, σ1, RyR2, TrkA/B agonist, 5-HT2/6/7, M1-5 mAChR, histamine H1/4, α1-adr. antagonist, SERT, NET inhibitor, Kv1.1/7.2/7.3 K+, L-type Ca2+ channel blocker) Diltiazem Hydrochloride (L-type Ca2+ channel blocker, potential CNG channel blocker) KT5720 (PKA and PDK1 inhibitor, HCN channel blocker, potential GSK3, MEK, MSK1, PKB inhibitor) Loperamide Hydrochloride (FIASMA, μOR agonist, potential HCN channel blocker) |
GABA Receptors
Abamectin (GABA antagonist, F0F1-ATPase and adenine nucleotide translocator inhibitor) Apigenin (GABA-A positive modulator, potential microtubule depolymerization inducer) Baclofen (GABA-B agonist) (−)-Bilobalide (GABA-A antagonist) (+)-Bicuculline (NMDA potentiator, GABA-A antagonist) Bumetanide (NKCC symporter and KCC2 co-transporter inhibitor, potential GABA-A antagonist) Dehydroepiandrosterone (ERβ, NMDA, σ1 agonist, ERα and AR partial agonist, GABA-A antagonist) Delta Sleep Inducing Peptide (GABA potentiator, NMDA negative allosteric modulator) Emamectin B1 Benzoate (GABA potentiator) Eprinomectin (GABA potentiator) Etomidate (GABA-A agonist) Flumazenil (GABA-A antagonist) Flumequine Sodium (bacterial DNA gyrase inhibitor, GABA-A antagonist) Flupirtine Maleate (Kv7 K+ channel activator, NMDA antagonist, GABA-A negative modulator) Furosemide (NKCC symporter inhibitor, CFTR Cl- channel blocker, GABA-A antagonist) Gabapentin (GABA potentiator, adenosine A1 agonist, voltage-gated α2δ Ca2+ channel blocker, NMDA modulator) Ginkgolide C (GABA-A, α-1 GlyR, PAF antagonist) Ginsenoside Rg3 (γ2 GABA-A agonist, Kv7.1 K+ channel activator, α10 nAChR antagonist) 20S-Ginsenoside Rg3 (Kv7.1 K+ channel activator, γ2 GABA-A agonist, α10 nAChR antagonist) Glabridin (GABA-A positive modulator) Honokiol (GABA-A potentiator) Isoflurane (Ca2+ ATPase and ATP-sensitive K+ channel activator, GABA-A and GlyR potentiator, NMDA antagonist, L-type Ca2+, delayed rectifier K+, A-type K+ channel blocker) Ivermectin (glu-gated Cl- channel activator, GlyR and GABA-A agonist) Magnolol (GABA-A potentiator) Mefenamic Acid (GABA-A potentiator, COX-1/2 inhibitor) Nicotinamide (GABA modulator) Niflumic Acid (NMDA inverse agonist, T-type Ca2+ and Cl- channel blocker, GABA-A antagonist, COX-1/2 inhibitor) Penitrem A (GABA-A potentiator, BK K+ channel inhibitor) Pregnenolone (TRPM3 agonist, NMDA potentiator, GABA-A negative allosteric modulator) Protopanaxadiol (GABA-A antagonist) Protopanaxatriol (GABA-A/C antagonist, slow-activating delayed rectifier K+ channel blocker) Puerarin (5-HT2C and GABA-A antagonist) Puerarin (GABA-A potentiator, 5-HT2C antagonist) Rosmarinic Acid (GABA transaminase and Fyn kinase inhibitor) Securinine (potential GABA-A antagonist) Somatostatin-14 (somatostatin agonist, GABA modulator, P/Q-type, N-type, and L-type voltage-gated Ca2+ channel modulator) Somatostatin-25 (somatostatin agonist, GABA modulator, P/Q-type, N-type, and L-type voltage-gated Ca2+ channel modulator) Somatostatin-28 (somatostatin agonist, GABA modulator, P/Q-type, N-type, and L-type voltage-gated Ca2+ channel modulator) Somatostatin-28 (1-12) (somatostatin agonist, GABA modulator, P/Q-type, N-type, and L-type voltage-gated Ca2+ channel modulator) Somatostatin-28 (1-14) (somatostatin agonist, GABA modulator, P/Q-type, N-type, and L-type voltage-gated Ca2+ channel modulator) [Tyr1]-Somatostatin (somatostatin agonist, GABA modulator, P/Q-type, N-type, and L-type voltage-gated Ca2+ channel modulator) [Tyr11]-Somatostatin (somatostatin agonist, GABA modulator, P/Q-type, N-type, and L-type voltage-gated Ca2+ channel modulator) Taurine (GABA-A and GlyR agonist) Verruculogen (BK K+ channel blocker, GABA-A antagonist) Yangonin (CB1 agonist, GABA-A potentiator) γ-Amino Butyric Acid (GABA agonist) |
Gap Junction Channels
Carbenoxolone (11β-HSD inhibitor, gap junction connexin channel blocker) Carbenoxolone Disodium (connexin and 11β-hydroxysteroid dehydrogenase inhibitor) |
Glycine Receptors
Ginkgolide B (GlyR antagonist) Ginkgolide C (GABA-A, α-1 GlyR, PAF antagonist) Isoflurane (Ca2+ ATPase and ATP-sensitive K+ channel activator, GABA-A and GlyR potentiator, NMDA antagonist, L-type Ca2+, delayed rectifier K+, A-type K+ channel blocker) Ivermectin (glu-gated Cl- channel activator, GlyR and GABA-A agonist) Taurine (GABA-A and GlyR agonist) |
Ionotropic Glutamate Receptors
L-Alliin (NMDA NR2A/2B agonist) Amantadine Hydrochloride (Viral M2 proton channel blocker, MAO-A, NET, NMDA, α7 nAChR antagonist) Amantadine Sulfate (Viral M2 proton channel blocker, MAO-A, NET, NMDA, α7 nAChR antagonist) trans-Anethole (NMDA agonist) Aniracetam (AMPA positive allosteric modulator, D2, 5-HT2A, nAChR agonist) Atomoxetine Hydrochloride (NET and SERT inhibitor, NMDA antagonist) (+)-Bicuculline (NMDA potentiator, GABA-A antagonist) Chlortetracycline Hydrochloride (protein translation inhibitor, MMP and calpain inhibitor, NMDA antagonist) D-Cycloserine (NMDA partial agonist, D-Ala-D-Ala ligase inhibitor) Dehydroepiandrosterone (ERβ, NMDA, σ1 agonist, ERα and AR partial agonist, GABA-A antagonist) Delta Sleep Inducing Peptide (GABA potentiator, NMDA negative allosteric modulator) Dextromethorphan Hydrobromide Hydrate (σ1/2and μ/κ/δ-OR agonist, α3β4/α4β2/α7 nAChR, SERT, NET, NMDA antagonist) Dihydrokainic Acid (NMDA agonist, GLT-1 inhibitor) Dimebon Dihydrochloride (AMPK activator, L-type Ca2+ channel and NMDA, histamine H1/2, α-adrenergic, 5-HT2C/5A/6 receptor antagonist) Flupirtine Maleate (Kv7 K+ channel activator, NMDA antagonist, GABA-A negative modulator) Flutriafol (demethylation inhibitor, NMDA agonist) Gabapentin (GABA potentiator, adenosine A1 agonist, voltage-gated α2δ Ca2+ channel blocker, NMDA modulator) (−)-Huperzine A (AChE inhibitor, NMDA antagonist) Kainic Acid (AMPA and kainate agonist) Memantine Hydrochloride (D2 agonist, NMDA, 5-HT3, α7 nAChR antagonist) Nefiracetam (NMDA and mGluR5 agonist, N-type and L-type Ca2+ channel activator, α4β2 nAChR potentiator) Niflumic Acid (NMDA inverse agonist, T-type Ca2+ and Cl- channel blocker, GABA-A antagonist, COX-1/2 inhibitor) Nobiletin (potential AMPA positive modulator) Pregnenolone (TRPM3 agonist, NMDA potentiator, GABA-A negative allosteric modulator) Rhyncholphylline (hERG K+ and L-type Ca2+ channel channel blocker, NMDA antagonist) Risperidone (5-HT7 and NMDA agonist, D-amino acid oxidase inhibitor, 5-HT2A and D2 antagonist) Sulfasalazine (sepiapterin reductase inhibitor, NMDA antagonist) L-Theanine (weak AMPA and NMDA agonist) Trimetazidine (Long-chain 3-ketoacyl-CoA thiolase inhibitor, potential kainate and AMPA antagonist) |
Nicotinic Acetylcholine Receptors
Amantadine Hydrochloride (Viral M2 proton channel blocker, MAO-A, NET, NMDA, α7 nAChR antagonist) Amantadine Sulfate (Viral M2 proton channel blocker, MAO-A, NET, NMDA, α7 nAChR antagonist) Anabasine Hydrochloride (depolarizing NMJ blocker; nAChR antagonist, aromatase inhibitor, teratogen) Aniracetam (AMPA positive allosteric modulator, D2, 5-HT2A, nAChR agonist) Atracurium Besylate (AChR antagonist) Bupropion Hydrochloride (α3β2, α3β4, α4β2 nAChR antagonist, indirect DA and NE reuptake inhibitor) Cisatracurium Besylate (nAChR and M2 mAChR antagonist) α-Conotoxin GI (nAChR inhibitor) α-Conotoxin IMI (α7 nAChR inhibitor) Cytisine (α3β4 nAChR agonist, α4β2 partial agonist) 13-Desmethyl Spirolide C (nAChR and mAChR antagonist) Dextromethorphan Hydrobromide Hydrate (σ1/2and μ/κ/δ-OR agonist, α3β4/α4β2/α7 nAChR, SERT, NET, NMDA antagonist) Dimethyl Fumarate (nAChR agonist, indirect Nrf2 activator) Galantamine Hydrobromide (AChE inhibitor, α7 nAChR agonist, mAChR agonist) Ginsenoside Rg3 (γ2 GABA-A agonist, Kv7.1 K+ channel activator, α10 nAChR antagonist) 20S-Ginsenoside Rg3 (Kv7.1 K+ channel activator, γ2 GABA-A agonist, α10 nAChR antagonist) Hexamethonium Bromide Hydrate (nAChR antagonist) Levamisole Hydrochloride (alkaline phosphatase inhibitor, potential nAChR agonist) Mecamylamine Hydrochloride (nAChR antagonist) Memantine Hydrochloride (D2 agonist, NMDA, 5-HT3, α7 nAChR antagonist) 12-Methyl Gymnodimine (nAChR antagonist) Mivacurium Chloride (nAChR antagonist) Nefiracetam (NMDA and mGluR5 agonist, N-type and L-type Ca2+ channel activator, α4β2 nAChR potentiator) Nordihydroguaiaretic Acid (5-lipoxygenase, AChR, BChE, mTORC1 inhibitor) Oxcarbazepine (α4β2 nAChR desensitizer, delayed-rectifier voltage-gated K+ and voltage-gated Na+ channel blocker) Pancuronium Bromide (nAChR antagonist) Penicillin G procaine (penicillin binding protein inhibitor, potential nAChR antagonist) Progesterone (PR agonist, mineralocorticoid, nAChR, σ1/2 antagonist) Pyrantel Pamoate (nAChR inhibitor) Rocuronium Bromide (nAChR and M2/3 mAChR antagonist) Tropisetron Hydrochloride (α7 nAChR partial agonist, 5-HT3 antagonist) Vecuronium Bromide (nAChR antagonist) |
P2X Receptors
Neomycin Sulfate (protein translation inhibitor, cation channel/receptor (P2X, TRPV1) blocker) Paromomycin Sulfate (protein translation inhibitor, cation (PX2X) channel blocker) Spinorphin, cow (P2X3 and N-formylpeptide antagonist, ACE, enkephalinase, aminopeptidase IV, neutral endopeptidase, DPP3 inhibitor) |
Potassium Channels
Allicin (inwardly rectifying K+ channel activator, L-type Ca2+ channel blocker) Allicin, aqueous (Kir K+ channel activator, L-type Ca2+ channel blocker) Amiodarone Hydrochloride (Voltage-gated Na+, Ca2+, K+ channel blocker, α/β-adrenergic antagonist, FIASMA) Amoxapine (5-HT2/3/6/7, D2/3/4, histamine H1, α1-adrenergic antagonist, SERT and NET inhibitor, hERG K+ channel blocker) Amsacrine (topoisomerase II inhibitor, hERG K+ channel blocker) Apamin (SK2/3/4 K+ channel blocker) Bombesin (bombesin and GRP agonist, hERG K+ channel blocker) [Tyr4]-Bombesin (bombesin and GRP agonist, hERG K+ channel blocker) Bupivacaine (BK/SK, Kv1, Kv3, TASK-2 K+ channel blocker, voltage-gated Na+ channel blocker) Bupivacaine Hydrochloride Monohydrate (voltage-gated Na+, BK/SK, Kv1, Kv3, TASK-2 K+ channel inhibitor) Carbamazepine (voltage-gated Na+ and ATP-sensitive K+ channel blocker) Catch-Relaxing Peptide (BK/SK K+ channel modulator) Clomipramine Hydrochloride (FIASMA, mAChR, 5-HT2/3/6/7, α1/2-adrenergic antagonist, SERT and NET inhibitor, hERG K+ and L-type Ca2+ channel blocker) Clozapine (M4 mAChR agonist, 5-HT1A partial agonist, M1/2/3/5 mAChR, D2 antagonist, Kv1.1 K+ channel blocker) Cyclovirobuxine D (hERG K+ channel inhibitor) Cytochalasin A (actin polymerization inhibitor, Kv1.5 K+ channel blocker.) Diclofenac Sodium (COX-1/2 inhibitor, potential K+ channel modulator) Dihydrocytochalasin B (actin polymerization inhibitor, Kv1.1-A-type K+ channel converter) α,β-Dihydroresveratrol (potential voltage-gated K+ channel modulator) Domperidone (D2/3 antagonist, hERG K+ channel blocker) Doxapram Hydrochloride Hydrate (K+ channel blocker, catecholamine release stimulator) Doxepin Hydrochloride (FIASMA, 5-HT1/2, M1-5 mAChR, α1-adrenergic, histamine H1/2 antagonist, SERT, NET, H+/K+ ATPase inhibitor) Efaroxan Hydrochloride (α2-adrenergic and imidazoline-1 antagonist, ATP-sensitive K+ channel blocker) Flufenamic Acid (TREK1 K+ potentiator, voltage-gated Na+ channel blocker, TRPC3 and TRPM2 antagonist, COX-1/2 inhibitor) Fluphenazine Hydrochloride (FIASMA, D2 antagonist, hERG K+ channel blocker) Flupirtine Maleate (Kv7 K+ channel activator, NMDA antagonist, GABA-A negative modulator) FMRF Amide (delayed rectifier K+ channel modulator) FMRF-like Peptide, snail (delayed rectifier K+ channel modulator) Ginsenoside Rg3 (γ2 GABA-A agonist, Kv7.1 K+ channel activator, α10 nAChR antagonist) 20S-Ginsenoside Rg3 (Kv7.1 K+ channel activator, γ2 GABA-A agonist, α10 nAChR antagonist) Glimepiride (ATP-sensitive K+ channel blocker) Glipizide (ATP-sensitive K+ channel blocker) 18β-Glycyrrhetinic Acid (15-HPGDH inhibitor, hERG and KCNA3/Kv1.3 K+ channel blocker) Iloperidone (D2 and 5-HT2A antagonist, potential hERG K+ channel blocker) Imiquimod (TLR-7/8 agonist, KCNA1/Kv1.1 and KCNA2/Kv1.2 K+ channel partial agonist, TREK-1/K2P2 and TRAAK/K2P4 K+ channel blocker) Indapamide (Kv7.1 and minK K+ channel blocker) Isoflurane (Ca2+ ATPase and ATP-sensitive K+ channel activator, GABA-A and GlyR potentiator, NMDA antagonist, L-type Ca2+, delayed rectifier K+, A-type K+ channel blocker) Levosimendan (Ca2+ sensitizer; ATP-sensitive K+ channel activator, troponin C stabilizer, PDE inhibitor) Mitiglinide Calcium (ATP-sensitive K+ channel blocker, potential RyR agonist) Moguisteine (Potential ATP-sensitive K+ channel blocker, potential irritant receptor antagonist) Nefazodone Hydrochloride (5-HT2 antagonist, SERT and NET inhibitor, hERG K+ channel blocker) Nifekalant Hydrochloride (Voltage-gated K+ channel blocker) Nocistatin (TRPC agonist, BK/SK K+ channel modulator) Oxcarbazepine (α4β2 nAChR desensitizer, delayed-rectifier voltage-gated K+ and voltage-gated Na+ channel blocker) Paxilline (BK K+ channel inhibitor, SERCA inhibitor) Penicillic Acid (BK K+, voltage-gated cardiac Na+, K+, Ca2+ channel inhibitor) Penitrem A (GABA-A potentiator, BK K+ channel inhibitor) Phentolamine Hydrochloride (ATP-sensitive K+ channel activator, α-adrenergic antagonist) Phentolamine Methanesulfonate (ATP-sensitive K+ channel activator, α-adrenergic antagonist) Pipemidic Acid (bacterial DNA gyrase inhibitor and ATP-sensitive K+ channel blocker) Propafenone Hydrochloride (β-adrenergic antagonist, Kv1.4 and K2P2 K+ channel blocker) Protopanaxatriol (GABA-A/C antagonist, slow-activating delayed rectifier K+ channel blocker) Repaglinide (ATP-sensitive K+ channel blocker) Rhyncholphylline (hERG K+ and L-type Ca2+ channel channel blocker, NMDA antagonist) Ritodrine Hydrochloride (β2-adrenergic agonist, SK/BK and ATP-sensitive K+ channel activator) Sarafotoxin 6c (ET-B agonist, ATP-sensitive K+ channel activator) Simvastatin (HMG-CoA reductase inhibitor, potential ATP-sensitive K+ channel activator, L-type Ca2+ channel blocker) Sotalol Hydrochloride (β-adrenergic antagonist, voltage-gated Na+ and K+ channel blocker) Speract (K+ channel activator, speract SRCR agonist) Tetrahydroberberine (5-HT1A agonist, D2 antagonist, ATP-sensitive K+ channel blocker) D,L-Tetrahydropalmatine (D1/2 antagonist, potential L-type Ca2+ and K+ channel blocker) Thioridazine Hydrochloride (FIASMA, D1-5, histamine H1/2, M1-5 mAChR, 5-HT1/2/5/6/7, α1/2-adrenergic antagonist, NET inhibitor, hERG K+ channel inhibitor) Trazodone Hydrochloride (5-HT1A partial agonist, 5-HT2, histamine, α1/2-adrenergic antagonist, SERT inhibitor, voltage-gated K+ channel blocker) Trimebutine Base (BK K+ channel and L-type Ca2+ channel blocker) Trimebutine Maleate (L-type Ca2+ channel blocker, BK K+ channel modulator, potential opioid agonist) Troglitazone (PPARγ agonist, ATP-sensitive K+ channel blocker) Tyrphostin A25 (SK K+ channel blocker, EGFR inhibitor) Verruculogen (BK K+ channel blocker, GABA-A antagonist) Vindoline (Kv2.1 K+ channel blocker and H+/K+ ATPase inhibitor) Voglibose (α-glucosidase inhibitor, potential GLP-1 agonist, potential ATP-sensitive K+ channel activator) |
Ryanodine Receptors
Amitriptyline Hydrochloride (FIASMA, σ1, RyR2, TrkA/B agonist, 5-HT2/6/7, M1-5 mAChR, histamine H1/4, α1-adr. antagonist, SERT, NET inhibitor, Kv1.1/7.2/7.3 K+, L-type Ca2+ channel blocker) Dantrolene Sodium Heptahydrate (RyR antagonist, L-type Ca2+ channel blocker) Mitiglinide Calcium (ATP-sensitive K+ channel blocker, potential RyR agonist) Suramin Hexasodium (RyR agonist, SIRT, telomerase, P2Y, GPCR inhibitor) |
Sodium Channels
Aconitine (voltage-gated Na+ channel modulator) Amiloride Hydrochloride Dihydrate (ENaC and acid-sensing ion channel blocker, Na+/H+ antiporter inhibitor) Amiodarone Hydrochloride (Voltage-gated Na+, Ca2+, K+ channel blocker, α/β-adrenergic antagonist, FIASMA) Brevetoxin 2 (Nav1.4/1.5 Na+ channel activator) Brevetoxin 3 (Nav1.4/1.5 Na+ channel activator) Bulleyaconitine A (voltage-gated Na+ channel blocker) Bupivacaine (BK/SK, Kv1, Kv3, TASK-2 K+ channel blocker, voltage-gated Na+ channel blocker) Bupivacaine Hydrochloride Monohydrate (voltage-gated Na+, BK/SK, Kv1, Kv3, TASK-2 K+ channel inhibitor) Carbamazepine (voltage-gated Na+ and ATP-sensitive K+ channel blocker) Clonidine Hydrochloride (Imidazoline and α2-adrenergic agonist, Nav1.7 Na+ channel blocker) Dihydromethysticin (Voltage-gated Na+ and L-type Ca2+ channel blocker) Diphenhydramine Hydrochloride (Voltage-gated Na+ channel blocker, mAChR antagonist, histamine H1 inverse agonist) Duloxetine Hydrochloride (SERT and NET inhibitor, Nav1.7 Na+ channel blocker) Flufenamic Acid (TREK1 K+ potentiator, voltage-gated Na+ channel blocker, TRPC3 and TRPM2 antagonist, COX-1/2 inhibitor) Hypaconitine (voltage-gated Na+ channel modulator) Imperatorin (voltage-gated Na+ channel blocker, AChE and BChE inhibitor) Kawain (Voltage-gated Na+ and L-type Ca2+ channel blocker) Lamotrigine (R-type Ca2+ and voltage-gated Na+ channel blocker) Lappaconitine (cardiac Na+ channel blocker) Oxcarbazepine (α4β2 nAChR desensitizer, delayed-rectifier voltage-gated K+ and voltage-gated Na+ channel blocker) Penicillic Acid (BK K+, voltage-gated cardiac Na+, K+, Ca2+ channel inhibitor) Proxymetacaine Hydrochloride (Potential voltage-gated Na+ channel blocker) Ranolazine Dihydrochloride (Nav1.7 and Nav1.8 N1+ channel blocker) Riluzole (TRPC5 agonist, PTR1 inhibitor, voltage-gated Na+ channel blocker, GLT-1 modulator) Sotalol Hydrochloride (β-adrenergic antagonist, voltage-gated Na+ and K+ channel blocker) Terbutaline (β2-adrenergic agonist, potential ENaC activator) Trifluoperazine Dihydrochloride (D1/2 and α1-adrenergic antagonist, calmodulin and CDPK4 inhibitor, Nav1.4 and Nav1.7 Na+ channel blocker) Valproic Acid Sodium (T-type Ca2+ and voltage-gated Na+ channel blocker, GABA transaminase and HDAC inhibitor) Zonisamide (carbonic anhydrase inhibitor, voltage-gated Na+ and T-type Ca2+ channel blocker) |
Transient Receptor Potential Channels
D,L-1′-Acetoxychavicol Acetate (TRPA1 agonist, xanthine oxidase inhibitor) Arvanil (CB1 agonist, TRPV1 agonist) AS-252424 (p110γ PI3K inhibitor, potential TRPC1/5/6 negative modulator, potential TRPC3/7 positive modulator) Azelastine Hydrochloride (TRPV1 agonist, histamine H1 antagonist) Capsaicin, natural (TRPV agonist) Carveol (TRPV3 agonist) Cromolyn Sodium (potential TRP antagonist, potential Cl- channel blocker) Etodolac (TRPA1 agonist, COX-2 inhibitor) Flufenamic Acid (TREK1 K+ potentiator, voltage-gated Na+ channel blocker, TRPC3 and TRPM2 antagonist, COX-1/2 inhibitor) Ginsenoside Rc (AMPK inhibitor, potential TRPV1 antagonist) Ginsenoside Rd (26S proteasome inhibitor, TRPM7 antagonist) (+)-Ketanserin Tartrate (5-HT2A and TRPV1 antagonist, potential α1-adrenergic antagonist) Lomerizine Dihydrochloride (L-type and T-type Ca2+ and TRP antagonist) Methyl Salicylate (TRPV1 modulator) Neomycin Sulfate (protein translation inhibitor, cation channel/receptor (P2X, TRPV1) blocker) Nocistatin (TRPC agonist, BK/SK K+ channel modulator) Parthenolide (TRPA1 partial agonist, NLRP3 and caspase 1 inhibitor) Peimine (TRPV1 and TRPA1 antagonist) Peiminine (M2 mAChR antagonist, potential TRPV1 and TRPA1 antagonist) Pimecrolimus (Calcineurin inhibitor, potential TRPV1 agonist) Piperine (TRPV1 agonist) Pregnenolone (TRPM3 agonist, NMDA potentiator, GABA-A negative allosteric modulator) Resiniferatoxin (PKC and TRPV agonist) Riluzole (TRPC5 agonist, PTR1 inhibitor, voltage-gated Na+ channel blocker, GLT-1 modulator) Sumatriptan Succinate (5-HT1B/1D agonist, TRPV1 antagonist) Tranilast (TRPV2 antagonist, PDGFR inhibitor) Zerumbone (potential TRPV1 antagonist) |

- New: PODS™ - Slow Release Growth Factors
- New: Coronavirus Research Tools
- Ebola Antibodies and Antigens
- LentiBOOST pharma grade non-GMP material
- Multiplexed bead-based immunoassays
- C-Slide - The New Name for Countess Slides
- New: C80EZ Cryopreservation Media - -80C Safe Cell Storage
- RNA Extraction Kit from Fresh Cells
