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iclines

High-throughput Toxicology Assay

The High-Throughput Toxicology Assay evaluates compound effects on the viability of adult human iPSC cardiomyocytes in a 96 well plate format.
 
The potential for cardiotoxicity is a major consideration in the design and development of therapeutic agents. Currently used preclinical cardiomyocyte models, such as in vivo animal testing or primary cell testing, are plagued by supply limitations, questionable relevance, and inconsistency with respect to genetic background. Adult human iPSC cardiomyocytes are now manufactured through uniform protocols and offer a uniform genetic background for consistent results. When coupled with electrophysiology assays, a cardiac safety ratio for a new therapeutic agent can be determined.
 
toxassay
 

References

  1. Schweikart, K., Guo, L., Shuler, Z., Abrams, R., Chiao, E.T., Kolaja, K.L., et al. (2013). The effects of jaspamide on human cardiomyocyte function and cardiac ion channel activity. Toxicology In Vitro, 27(2), 745-751.
  2. Reynolds, J.G., Geretti, E., Hendriks, B.S., Lee, H., Leonard, S.C., Klinz, S.G., et al. (2012). HER2-targeted liposomal doxorubicin displays enhanced anti-tumorigenic effects without associated cardiotoxicity. Toxicology and Applied Pharmacology, 262(1), 1-10.
 
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