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Enzymes Modulator Array Library

Library Code: T-VDAEnz
 
Enzymes are incredibly useful tools in a wide range of disciplines and industrial processes. Snake venoms are a rich source of enzymes such as phospholipases (PLA2), snake venom metalloproteinase (SVMP), phophodiesterases, L-amino-acid oxidase (LAO) and many more. Moreover, invertebrate venoms also often contain enzymes such as phospholipase. The Enzymes Targeted Venom Discovery Array™ libraries contain pure venom fractions from 12, 24, 48 or 96 species optimized for identification of novel tools. Each array contains literature-cited, characterized venoms as positive controls. Other venom fractions making up the library have been specially selected by our drug discovery scientists to maximize novel hit potential.
 
T-VDAEnz control venoms include:
  • Phospholipase A2-containing Naja nigricollis venom (black-necked spitting cobra)1
  • Deinagkistrodon acutus (hundred pace pit viper) which contains an L-amino-acid oxidase enzyme that induces apoptosis in HeLa cancer cells2
  • Crotalus adamanteus (Eastern diamondback rattlesnake) venom which contains snake venom metalloproteinases such as Adamalysin3
References
  1. Stefansson S., Kini R.M., Evans H.J. (1990). The basic phospholipase A2 from Naja nigricollis venom inhibits the prothrombinase complex by a novel nonenzymatic mechanism. Biochemistry 29:7742-7746
  2. Zhang L., Wei L. (2007). ACTX-8, a cytotoxic L-amino acid oxidase isolated fromDeinagkistrodon acutus snake venom, induces apoptosis in Hela cervical cancer cells. J. Life Sci. 80:1189-1197
  3. Gomis-Rueth F.-X., Meyer E.F., Kress L.F., Politi V. (1998). Structures of adamalysin II with peptidic inhibitors. Implications for the design of tumor necrosis factor alpha convertase inhibitors. Protein Sci. 7:283-292
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