Enzymes Modulator Array Library
Library Code: T-VDAEnz
Enzymes are incredibly useful tools in a wide range of disciplines and industrial processes. Snake venoms are a rich source of enzymes such as phospholipases (PLA2), snake venom metalloproteinase (SVMP), phophodiesterases, L-amino-acid oxidase (LAO) and many more. Moreover, invertebrate venoms also often contain enzymes such as phospholipase. The Enzymes Targeted Venom Discovery Array™ libraries contain pure venom fractions from 12, 24, 48 or 96 species optimized for identification of novel tools. Each array contains literature-cited, characterized venoms as positive controls. Other venom fractions making up the library have been specially selected by our drug discovery scientists to maximize novel hit potential.
T-VDAEnz control venoms include:
- Phospholipase A2-containing Naja nigricollis venom (black-necked spitting cobra)1
- Deinagkistrodon acutus (hundred pace pit viper) which contains an L-amino-acid oxidase enzyme that induces apoptosis in HeLa cancer cells2
- Crotalus adamanteus (Eastern diamondback rattlesnake) venom which contains snake venom metalloproteinases such as Adamalysin3
References
- Stefansson S., Kini R.M., Evans H.J. (1990). The basic phospholipase A2 from Naja nigricollis venom inhibits the prothrombinase complex by a novel nonenzymatic mechanism. Biochemistry 29:7742-7746
- Zhang L., Wei L. (2007). ACTX-8, a cytotoxic L-amino acid oxidase isolated fromDeinagkistrodon acutus snake venom, induces apoptosis in Hela cervical cancer cells. J. Life Sci. 80:1189-1197
- Gomis-Rueth F.-X., Meyer E.F., Kress L.F., Politi V. (1998). Structures of adamalysin II with peptidic inhibitors. Implications for the design of tumor necrosis factor alpha convertase inhibitors. Protein Sci. 7:283-292
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