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Chromatin-modifying Enzyme Compounds

Inhibitors and modulators are available for a wide range of chromatin-modifying enzyme targets.

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Chromatin-modifying Enzyme Categories

Histone Deacetylases (HDACs)

Histone Demethylases

Histone Methyltransferases (HMTs)


Histone Deacetylases (HDACs)

AK-1 (SIRT2 inhibitor)

AK-7 (SIRT2 inhibitor)

Apicidin (HDAC inhibitor)

Belinostat (HDAC inhibitor)

Bisdemethoxycurcumin (DNMT1 and α-amylase inhibitor, WIF-1 promoter demethylation inhibitor, potential SIRT1 and AMPK activator)

n-Butyric Acid (HDAC inhibitor)

Butyric Acid Sodium (HDAC inhibitor, RNA splicing modulator)

Cambinol (SIRT inhibitor)

Ceramide (sphingosine-1-phosphate agonist, potential HDAC inhibitor)

Chrysin (HDAC2/8 inhibitor, potential aromatase inhibitor)

CUDC-907 (PI3K and HDAC inhibitor)

Ellagic Acid (HDAC modulator)

Entinostat (HDAC1 inhibitor)

EX-527 (SIRT1 inhibitor)

Isoliquiritigenin, natural (SIRT activator, GABA-A positive modulator, NMDA antagonist, VEGFR2 and HDAC inhibitor)

LBH-589 (HDAC1/2/3/11 inhibitor)

Lycorine Hydrochloride (protein synthesis inhibitor, potential peptidyltransferase and HDAC inhibitor)

MGCD-0103 (HDAC inhibitor)

N-Acetyl-S-(N′-phenylhexylthiocarbamoyl)-L-cysteine (HDAC inhibitor)

Phenylbutyrate Sodium (HDAC inhibitor)

Phenylhexyl Isothiocyanate (HDAC inhibitor)

Resveratrol (SIRT1 activator, MAO inhibitor)

Romidepsin (HDAC inhibitor)

Salermide (SIRT inhibitor)

Scriptaid (HDAC inhibitor)

Sphingosine-1-Phosphate (sphingosine-1-phosphate agonist, potential HDAC inhibitor)

Splitomicin (SIRT1/2 inhibitor)

SRT1720 Hydrochloride (SIRT 1 activator, SIRT3 inhibitor)

Suramin Hexasodium (RyR agonist, SIRT, telomerase, P2Y, GPCR inhibitor)

Tenovin-1 (SIRT1/2 inhibitor, indirect p53 activator)

Tenovin-6 (SIRT1/2 inhibitor, indirect p53 activator)

trans-3,4′,5-Trimethoxy Stilbene (potential SIRT1 activator)

Triacetyl Resveratrol (potential SIRT1 activator)

Trichostatin A (HDAC inhibitor, mammalian RNA splicing modulator)

Tubacin (HDAC6 inhibitor)

Tubastatin A Hydrochloride (HDAC6/10 inhibitor)

n-Valeric Acid (potential HDAC inhibitor)

Valproic Acid Sodium (T-type Ca2+ and voltage-gated Na+ channel blocker, GABA transaminase and HDAC inhibitor)

Vorinostat (HDAC inhibitor, RNA splicing inhibitor)


Histone Demethylases

Tranylcypromine Hydrochloride (MAO and histone demethylase LSD1 inhibitor)

Histone Methyltransferases (HMTs)

5-Aza-2′-deoxycytidine (DNMT inhibitor, protein synthesis inhibitor)

Azacitidine (DNMT inhibitor, protein synthesis inhibitor)

Chlorogenic Acid (DNMT and G6P translocase inhibitor, potential pepsin inhibitor)

EPZ005687 (EZH2 HMT inhibitor)

EPZ-5676 (DOT1L HMT inhibitor)

EPZ6438 (EZH2 inhibitor)

GSK-126 (EZH2 HMT inhibitor)

GSK-343 (EZH2 HMT inhibitor)

Mithramycin (DNMT 1 inhibitor, RNA synthesis inhibitor)