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Cancer Therapeutics Array Library

Library Code:  T-VDAOncol
Venoms are a proven therapeutic resource with several drugs in development for cancer therapeutics such as antimetastics and tumor cell apoptosis. Snake venoms are rich source of new oncology tools including disintegrins, L-amino-acid oxidase and a wealth of signaling peptides. The Oncology Targeted Venom Discovery Array™ libraries contain pure venom fractions from 12, 24, 48 or 96 species optimized for identification of novel tools. Each array contains literature-cited, characterized venoms active in analgesic pathways as positive controls. The other venom fractions making up the library have been specially selected by our drug discovery scientists to maximize novel hit potential.
T-VDAOncol control venoms include:
  • Agkistrodon contortrix (Southern copperhead) where the disintegrin Contortrostatin was discovered1
  • Deinagkistrodon acutus (hundred pace pit viper) which contains an L-amino acid oxidase enzyme that induces apoptosis in HeLa cancer cells2
  • Leiurus quinquestriatus (death stalker scorpion) venom which contains small neurotoxic peptides that block chloride channels and can label gliomas3
  1. Zhou Q., Hu P., Ritter M.R., Swenson S.D., Argounova S., Epstein A.L., Markland F.S. Arch. (2000). Molecular cloning and functional expression of contortrostatin, a homodimeric disintegrin from southern copperhead snake venom. Biochem. Biophys. 375:278-288
  2. Zhang L. & Wei L.J. (2007) ACTX-8, a cytotoxic L-amino acid oxidase isolated fromAgkistrodon acutus snake venom, induces apoptosis in HeLa cervical cancer cells. Life Sci. 80:1189-1197
  3. Soroceanu L., Gillespie Y., Khazaeli M.B., Sontheimer H. (1998). Use of chlorotoxin for targeting of primary brain tumors. Cancer Res. 58:4871-4879
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