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Anticoagulants Array Library

Library Code: T-VDAacog
 
Anticoagulants are important drug tools for a range of cardiovascular disorders including heart attack and stroke. Alongside leeches, venoms from snakes and jelly fish are also rich sources of new anticoagulants. The Anticoagulant Targeted Venom Discovery Array™ libraries contain pure venom fractions from 12, 24, 48 or 96 species optimized for identification of novel tools. Each array contains literature-cited, characterized venoms with anticoagulant activity as positive controls. The other venom fractions making up the library have been specially selected by our drug discovery scientists to maximize novel hit potential.
 
T-VDAacog control venoms include:
  • Naja kaouthia (monocled cobra) which contains fibrinogenolytic toxins1
  • Aurelia aurita (moon jellyfish) where the fibrinogenolytic activity can completely liquefy clots2
  • Hirudo verbana (medicinal leech) which famously also contains a diverse collection of anticoagulants3
References
  1. Sekhar, C. C. & Chakrabarty, D. (2011). Fibrinogenolytic toxin from Indian monocled cobra (Naja kaouthia) venom. Journal of Biosciences 36, 355–361.
  2. Rastogi, A., Biswas, S., Sarkar, A. & Chakrabarty, D. (2012). Anticoagulant activity of moon jellyfish (Aurelia aurita) tentacle extract. Toxicon 60, 719–723.
  3. Kvist, S., Min. G.S. Siddall, M.E. (2013). Diversity and selective pressures of anticoagulants in three medicinal leeches (Hirudinida: Hirudinidae, Macrobdellidae). Ecology and Evolution 3, 918.
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