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ALS Array Library

Library Code: T-VDAALS
 
One of the key pathologies seen in ALS muscular degeneration is excess calcium (Ca2+). Ca2+ channels are, therefore, important drug targets for this neurological disorder. Venoms from theraphosids (tarantulas), scorpions and snakes are rich sources of new Ca2+ channel tools. The ALS Targeted Venom Discovery Array ™ contains pure venom fractions from 12, 24, 48 or 96 species optimized for identification of novel tools. With a special focus on Grammastola species, other venom fractions making up the library have been specially selected by our drug discovery scientists to maximize novel hit potential.
 
T-VDAALS control venoms include: 
  • Parabuthus transvaalicus (South African fattail scorpion) which contains Kurtoxin with broad spectrum calcium channel activity L,T,N and P type channels1
  • Dendroaspis angusticeps (Eastern green mamba) venom which contains Calcicludin, a potent L-type calcium channel blocker2
  • Hysterocrates gigas (Cameroon red baboon tarantula) venom which blocks N and E type calcium currents3.
References  
  1. Chuang R.S.I., Jaffe H., Cribbs L., Perez-Reyes E., Swartz K (1998). Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin. J. Nat. Neurosci. 1:668-674
  2. Schweitz H., Heurteaux C., Bois P., Moinier D., Romey G., Lazdunski M. (1994). Calcicludine, a venom peptide of the Kunitz-type protease inhibitor family, is a potent blocker of high-threshold Ca2+ channels with a high affinity for L-type channels in cerebellar granule neurons. Proc. Natl. Acad. Sci. U.S.A. 91:878-882
  3. Newcomb R., Szoke B., Palma A., Wang G., Chen X.H., Hopkins W., Cong R., Miller J., Urge L., Tarczy-Hornoch K., Loo J.A., Dooley D.J., Nadasdi L., Tsien R.W., Lemos J., Miljanich G. (1998). Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas. Biochemistry 37:15353-15362
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