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New: Coronavirus Research Tools

New: Coronavirus Research Tools

Coronavirus Research Tools: Inhibitors

 Cutting edge small molecule reagents targeting key proteins and mechanisms of coronavirus infection.

We are going through an unprecedented time with the Covid-19 pandemic.  Scientists all over the world are coming together to accelerate diagnostics, and to produce vaccines and therapeutics for this novel coronavirus.

The Coronavirus SARS-CoV-2 causes Coronavirus Disease 2019 (COVID-19) by hijacking host cell mechanisms. Researchers and drug discovery scientists are applying two methods of approach in the small molecule arena. The first is repurposing existing compounds and the second is discovering new small molecules that specifically inhibit SARS-CoV-2.

Mayflower Bioscience offers a comprehensive list of Coronavirus inhibitors for research, benchmarking, and positive controls. For example, serine protease inhibitor Camostat mesilate blocks TMPRSS2 and possibly other proteases involved in infection. Umifenovir, Favipiravir, and Emetine are antivirals that block SARS-CoV-2 infection of cells. Tofacitinib is a kinase inhibitor that blocks the ‘cytokine storm’ mounted by the host immune system. Other mechanisms of action include inhibitors of bromodomains, HDACs, autophagy, mTOR, and sigma receptors; many are in clinical trials for COVID-19.

To view this comprehensive list, please go to www.mayflowerbio.com/home and click on the COVID-19 Research Compounds link.

 

Coronavirus research is here to stay, according to an article in Nature: 

https://www.nature.com/articles/d41586-020-01525-z?WT.ec_id=NATURE-20200611&utm_source=nature_etoc&utm_medium=email&utm_campaign=20200611&sap-outbound-id=EFF13FD62ACFDE87A1280FC46A99EDC5CC88642E