G-CSF, mouse recombinant
G-CSF is a glycoprotein containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. The synthesis of G-CSF can be induced by bacterial endotoxins, TNF, IL-1 and GM-CSF. Prostaglandin E2 inhibits the synthesis of G-CSF. In epithelial, endothelial, and fibroblastic cells secretion of G-CSF is induced by IL-17. Recombinant Mouse G-CSF is a single, non- glycosylated, polypeptide chain.
Peptides & proteins
CSF-3, MGI-1G, GM-CSFβ, pluripoietin
-20°C
NAME: Granulocyte Colony Stimulating Factor; ACCESSION/UNIPROT#: P09920; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium citrate, pH 3.0. Reconstitute in sterile water at 0.1 mg/mL.; TESTING: NFS-60 cell proliferation with an acceptance criteria of 50 pg/mL (ED50), 2 x 10^7 units/mg.; #AA: 179; SEQUENCE: MVPLVTVSAL PPSLPLPRSF LLKSLEQVRK IQASGSVLLE QLCATYKLCH PEELVLLGHS LGIPKASLSG CSSQALQQTQ CLSQLHSGLC LYQGLLQALS GISPALAPTL DLLQLDVANF ATTIWQQMEN LGVAPTVQPT QSAMPAFTSA FQRRAGGVLA ISYLQGFLET ARLALHHLA